LustGarden Foundation for Pancreatic Cancer Research

Pancreatic Cancer Research

As the largest private funder of pancreatic cancer research, we are relentlessly focused on improving patient outcomes and we are making progress every day. Thanks to separate funding to support administrative expenses, 100 percent of every donation goes directly to research.

Navigating Pancreatic Cancer

We are here to empower you to ask bold questions, seek out the best treatment options, and face the unique challenges of pancreatic cancer head-on. We want to give you the resources and information you need to make informed decisions that are best for you.

Patient Checklist


August 1, 2018 ladmin
As overwhelming as a pancreatic cancer diagnosis is, it is important to act quickly and put a treatment plan into place. Treatment should ideally begin within one month after you receive your diagnosis. Understand your disease. Thoroughly understand what stage of pancreatic cancer you have and inquire about having your blood and tumor genetically sequenced. […]
Lets Win! Pancreatic Cancer

Let’s Win! Pancreatic Cancer

July 20, 2018 ladmin
LET’S WIN! Pancreatic Cancer A Dynamic Way to Share Information Recognizing that there is an urgent need for patients to communicate amongst themselves and with the medical community about potentially life-changing treatments and clinical trials, we are proud to be affiliated with Let’s Win. Let’s Win is an interactive online community where patients and families […]

Pancreatic Cancer Connections

July 7, 2018 ladmin
Pancreatic Cancer Connections is online social community that provides a safe space for pancreatic cancer patients and their loved ones to share their experiences, get valuable coping resources, and support one another. Patients interact with others who are facing a pancreatic cancer and can post questions to the board or message other members privately. This community forum is a valuable resource for patients, caregivers, and their loved ones to refer to at various stages of their treatment and recovery. Patients and loved ones can sign up for Pancreatic Cancer Connections at no cost and will be welcomed into an engaging and supportive community to discuss topics including treatment options, nutrition, and coping with the disease. Pancreatic Cancer Connections is hosted by Inspire, a leading healthcare social network that connects more than 1,000,000 patients and caregivers.

Lustgarten News

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Career Development Awards Announced

The inaugural winners of the Lustgarten Foundation-AACR Career Development Awards for Pancreatic Cancer Research in Honor of Ruth Bader Ginsburg and John Robert Lewis were announced at the 2021 AACR annual meeting. For Dr. Avery Posey it was a bout with chickenpox when he was in 4th grade that spurred his interest in science. He was quarantined in one room for about a week and still remembers his grandmother lovingly applying calamine lotion to his blisters. “I was miserable, itchy, missed school, missed my friends, and all I kept thinking was there had to be a way to prevent this,” Posey says. A few years later, the chickenpox vaccine was unveiled and “most kids today don’t even know what chickenpox is,” he continues. “I thought for a while I wanted to be a doctor, but I realized in undergraduate school that real important changes in how we look at disease and treat disease is due to research.” Dr. Dannielle Engle thought she was going to be a violinist, a virtuoso maybe along the lines of Joshua Bell. She started college majoring in music, but switched gears and wound up majoring in biology. When she took a low-level job in a research lab while still an undergrad, it was the fruit fly and its simple genetic structure as well as the creativity shown by the investigators with whom she worked that made her realize science was her calling. “I was a pretty good violinist, not great,” she laughs. “But I got completely hooked on my work in the lab and I knew at that point my future was in research.”

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International Pancreatic Cancer Trial opens

 Researchers testing organoids use in predicting treatment outcomes

A new team of pioneering pancreatic cancer researchers has been formed to predict which treatments might work best for individual pancreatic cancer patients based on the molecular traits of tumors. The Pancreatic Cancer Convergence Dream Team is funded by the Pancreatic Cancer Collective, an initiative of the Lustgarten Foundation and Stand Up To Cancer® (SU2C), SU2C Canada and Pancreatic Cancer Canada. The team will be led by Jennifer Knox, MD, the Lewitt Chair in Pancreatic Cancer Research at the Princess Margaret Cancer Centre, part of University Health Network, and professor of medicine at the University of Toronto in Canada, and Elizabeth Jaffee, MD, a professor of oncology and deputy director of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in Baltimore, Maryland.

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Welcome to LustgartenLIVE! a new quarterly series of webinars designed to bring you face-to-face with the best researchers investigating pancreatic cancer. Moderated by Andrew Rakeman, PhD , Vice President of Research, each webinar in the series will focus on a different aspect of the research funded through your donations. Hope is on the horizon! REGISTRATION IS NOW OPEN for Early Detection: The Path Forward.
Though pancreatic cancer is considered a rare disease, it remains the third-leading cause of cancer-related death. Because we know earlier detection plays a key factor in saving and extending lives, the Lustgarten Foundation has designated early detection as a research funding priority. In this live discussion you’ll have access to the latest information from the lead scientists behind two of the most promising advances in early detection screenings:

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Pancreatic Cancer News

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Voruciclib Regimens Demonstrate Preliminary Potency Against KRAS-Positive Cancers

10. 4. 21 ladmin
The early results showed that voruciclib led to a rapid decrease in the phosphorylation of proteins that promote MYC transcription and quickly decreases phosphorylation of MYC protein on Serine 62 (Ser62), which is a site implicated in stabilizing MYC in KRAS-mutant cancers. Treatment with voruciclib, a CDK9 inhibitor, as a monotherapy or in combination with […]

Immune-stimulating drug before surgery shows promise in early-stage pancreatic cancer

10. 4. 21 ladmin
Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania. Changing the microenvironment from so-called T cell “poor” to T cell “rich” […]

Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis

10. 4. 21 ladmin
Researchers at The University of Texas MD Anderson Cancer Center have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact through the CREB1 protein to promote metastasis and tumor growth. Blocking CREB1 in preclinical models reversed these effects and reduced metastases, suggesting an important new therapeutic target for the […]

Saif Shares Key Treatment Considerations for Advanced Pancreatic Cancer

9. 4. 21 ladmin
Wasif Saif, MD, discusses factors to consider when choosing a frontline treatment strategy in pancreatic cancer, highlights the hunt for helpful biomarkers of response to available options, and offers sequencing suggestions. For patients with advanced pancreatic cancer, approved treatment regimens come with a host of factors to consider, as far as how they will be […]

Clinical trial helps pancreatic cancer patients

25. 3. 21 ladmin
When doctors diagnosed Brenda Scully’s husband with inoperable pancreatic cancer, she was in shock. Brenda said she tried not to show her emotions to him, staying strong, “I just called the kids and cried to them. And they were very supportive. And I just said to Vince, well, we can deal with this.” But her […]

UCLA team receives $6 million from NIH to explore new pancreatic cancer therapies

25. 3. 21 ladmin
A team of researchers from the UCLA Jonsson Comprehensive Cancer Center has been awarded two research grants totaling $6 million from the National Institutes of Health to identify new ways to treat pancreatic cancer. Pancreatic cancer is the third leading cause of cancer-related mortality in the United States, accounting for more than 47,000 deaths annually. […]

The Latest Quantified Self Trend: Whole-Body MRI

24. 3. 21 ladmin
I have always been interested in learning more about my body and how to use data to improve my health. When I had the opportunity to try a whole-body MRI scan from Prenuvo, a diagnostics company focusing on the early detection of cancer and other diseases, I was intrigued by what I learned. A magnetic […]

Scientists shrink pancreatic tumors by starving their cellular “neighbors

16. 3. 21 ladmin
Newswise — Scientists at Sanford Burnham Prebys Medical Discovery Institute demonstrated for the first time that blocking “cell drinking,” or macropinocytosis, in the thick tissue surrounding a pancreatic tumor slowed tumor growth—providing more evidence that macropinocytosis is a driver of pancreatic cancer growth and is an important therapeutic target. The study was published in Cancer Discovery, a journal […]

Cancer immunotherapy approach targets common genetic alteration

15. 3. 21 ladmin
Researchers developed a prototype for a new cancer immunotherapy that uses engineered T cells to target a genetic alteration common among all cancers. The approach, which stimulates an immune response against cells that are missing one gene copy, called loss of heterozygosity (LOH), was developed by researchers at the Ludwig Center, Lustgarten Laboratory and the Bloomberg~Kimmel Institute for Cancer […]

High-Dose Radiation Offers Hope for People with Inoperable Pancreatic Cancer

11. 3. 21 ladmin
Pancreatic cancer is notoriously difficult to treat, partly because surgery is not possible or is ineffective. MSK has developed a high-dose form of radiation therapy that can give safe, effective treatment to many patients who are unable to have surgery. Pancreatic cancer has proven very difficult to treat compared with more common cancers. Despite decades of […]

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