Discoveries

Cold Spring Harbor Laboratory (CSHL) is at the forefront of using organoid technology to study and treat cancer. Organoids are tiny 3D clusters of cells that are miniature versions of patients’ tumors. 

The annual American Society of Clinical Oncology (ASCO) meeting brings together scientists from across the country who are studying every type of cancer to share the latest results from the lab and the clinic. This year’s headlines focused heavily on a small study of immunotherapy in rectal cancer that achieved 100% remission in all 14 […]

With a five-year survival rate of only 11%, pancreatic cancer patients need more effective therapies. A new form of immunotherapy is showing promise, as it shrank metastases and stopped progression of one patient’s advanced pancreatic cancer after other forms of treatment had failed. The results were published in the June 1 issue of the New […]

Neoadjuvant gemcitabine-based chemoradiotherapy prolonged OS compared with upfront surgery among patients with resectable and borderline resectable pancreatic cancer, according to phase 3 study results in Journal of Clinical Oncology.

UTSW study identifies a subset of cancer-associated fibroblasts that offers a new target to attack deadly disease and break the shield that protects pancreatic cancer from immunotherapy.

A new study by Dana-Farber Cancer Institute researchers has given scientists their first look at the genomic landscape of tumors that have grown resistant to drugs targeting the abnormal KRASG12C protein. Their work shows that, far from adopting a common route to becoming resistant, the cells take a strikingly diverse set of avenues, often several […]

Cancer cells can become resistant to treatments through adaptation, making them notoriously tricky to defeat and highly lethal. Cold Spring Harbor Laboratory (CSHL) Cancer Center Director David Tuveson and his team investigated the basis of “adaptive resistance” common to pancreatic cancer. They discovered one of the backups to which these cells switch when confronted with […]

LA JOLLA–(June 10, 2021) In order for cancer to grow and spread, it has to evade detection by our immune cells, particularly specialized “killer” T cells. Salk researchers led by Professor Susan Kaech have found that the environment inside tumors (the tumor microenvironment) contains an abundance of oxidized fat molecules, which, when ingested by the […]