The Vogelstein Lab
A Lustgarten Distinguished Lab at Johns Hopkins University
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, based in Baltimore, Maryland, is a National Cancer Institute designated cancer center.
Lab Leadership: Bert Vogelstein, M.D.
Dr. Vogelstein is Director of the Ludwig Center, Clayton Professor of Oncology and Pathology and a Howard Hughes Medical Institute investigator at The Johns Hopkins Medical School and Kimmel Cancer Center.
Dr. Vogelstein has published more than 500 scientific papers and has been cited nearly 300,000 times more than those of any other scientist, in any discipline, in recorded history. If books, in addition to research papers are included, Dr. Vogelstein is ranked as the 8th most-cited scholar of all time, with Sigmund Freud ranking first.
We commissioned renowned cancer researcher Dr. Vogelstein to do a complete genetic analysis of pancreatic cancer. This research revealed that the disease is caused by a number of mutations acting together, rather than by a single gene. It also revealed that certain mutated pancreatic cancer genes are cancer-causing, while others are mutations that occur simply as a result of the cancer being formed. Most significantly, his findings demonstrated that the KRAS gene is mutated in nearly 100 percent of all pancreatic cancer tumors. This research marked the most comprehensive genetic sequencing that had ever been done for any cancer.