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Disrupting the Cellular Process That Promotes Pancreatic Cancer’s Deadly Growth

esearchers say they’ve identified a way to disrupt a process that promotes the growth of pancreatic cancers — one of the most difficult and deadly cancers to treat. The team, led by scientists at Georgetown Lombardi Comprehensive Cancer Center and including investigators from Lawrence Livermore National Laboratories, STCube and Fluidigm, published their findings today in […]

Nerves keep pancreatic cancer cells from starving

Pancreatic cancer cells avert starvation by signaling to nerves, which grow into dense tumors and secrete nutrients. This is the finding of a study with experiments in cancer cells, mice, and human tissue samples published online November 2 in Cell. The study addresses pancreatic ductal adenocarcinoma (PDAC), the deadliest cancer of the pancreas with a five-year […]

Testing drugs within a tumor may combat pancreatic cancer drug resistance, ‘time machine’ suggests

Many patients with pancreatic cancer have only about a 10% chance of survival within five years of their diagnosis because they tend to become resistant to chemotherapy, past studies have indicated. A “time machine” that Purdue University engineers designed to observe pancreatic cancer behavior over time suggests a new drug testing approach that could help scientists better […]

Ongoing Studies Could Modify the Script in Metastatic Pancreatic Cancer

Clinical trials should not be viewed as a last resort for patients with metastatic pancreatic cancer, explained Allyson Ocean, MD, who added that even frontline standards of care should be considered after exhausting all available study options. “There are plenty of clinical trials available for your patients. Clinical trials should always be the first consideration […]

New Radiation Therapy Helps Treat Inoperable Pancreatic Cancer

Pancreatic cancer is a serious and often fatal disease, but a September study published in Practical Radiation Oncology explores a new advancement in radiation therapy that may provide a better treatment option for some patients. Along with his colleagues, Michael Chuong, MD, study author and a board-certified radiation oncologist with the Miami Cancer Institute, studied 35 […]

Weight-Loss Surgery May Cut Pancreatic Cancer Risk in People With Diabetes

Weight-loss surgery significantly reduces the risk of pancreatic cancer in obese people with diabetes, a new study finds. For the study, the researchers analyzed 20 years of data from 1.4 million people, including more than 10,000 who’d had weight-loss surgery. About three-quarters of those who had weight-loss surgery were women. People who’d had weight-loss surgery […]

Single-cell RNA sequencing reveals details about individual cells in pancreatic tumors

Led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and by HonorHealth Research and Innovation Institute, an international team of researchers have described in detail the individual cells that comprise the pancreatic cancer microenvironment, a critical step in devising new treatment options for patients with this aggressive and difficult-to-treat disease. […]
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